The GHK-Cu (Glycyl-L-Histidyl-L-Lysine) peptide is a naturally occurring tripeptide that has numerous biological applications, due to its strong affinity for copper ions. This copper complex is involved in several physiological processes and has found relevance in the Netherlands fields of regenerative medicine, wound healing, and anti-aging treatments.
The mechanism of action of GHK-Cu is attributed to its ability to upregulate genes associated with tissue repair, anti-inflammatory response, and antioxidant defense systems. Netherlands Research suggests it stimulates collagen synthesis, angiogenesis, and the production of growth factors, contributing to enhanced wound healing and skin regeneration.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3359723/
[2] https://onlinelibrary.wiley.com/doi/ abs/10.1002/ppsc.201800420
[3] https://pubs.acs.org/doi/abs/ 10.1021/acssuschemeng.2c04422
[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6073405/
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8789089/
[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6073405/
[7] https://pubmed.ncbi.nlm.nih.gov/18644225/
[8] https://pubmed.ncbi.nlm.nih.gov/31809714/
[9] https://pubmed.ncbi.nlm.nih.gov/37062921/
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